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10937713
Source:
http://linkedlifedata.com/resource/pubmed/id/10937713
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0023621
,
umls-concept:C0178696
,
umls-concept:C0220781
,
umls-concept:C1883254
pubmed:issue
15
pubmed:dateCreated
2000-12-6
pubmed:abstractText
Synthesis of an arylsulfone hydroxamate lead optimization library is presented. Biological activity of representative examples is given to demonstrate the value of this approach for lead optimization.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-AMP Phosphodiesterases
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...
,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids
,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases
,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0960-894X
pubmed:author
pubmed-author:BurnsC JCJ
,
pubmed-author:DoddAA
,
pubmed-author:GronebergRR
,
pubmed-author:KiesowTT
,
pubmed-author:KlineJJ
,
pubmed-author:LabaudininiereRR
,
pubmed-author:MasonH JHJ
,
pubmed-author:MathewRR
,
pubmed-author:McGeehanGG
,
pubmed-author:MorrisetteMM
,
pubmed-author:NarensinghRR
,
pubmed-author:OrtonEE
,
pubmed-author:SalvinoJ MJM
,
pubmed-author:TangS YSY
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1637-40
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10937713-3',5'-Cyclic-AMP Phosphodiesterases
,
pubmed-meshheading:10937713-Cyclic Nucleotide Phosphodiesterases, Type 4
,
pubmed-meshheading:10937713-Enzyme Inhibitors
,
pubmed-meshheading:10937713-Hydroxamic Acids
,
pubmed-meshheading:10937713-Matrix Metalloproteinases
,
pubmed-meshheading:10937713-Structure-Activity Relationship
,
pubmed-meshheading:10937713-Sulfones
pubmed:year
2000
pubmed:articleTitle
Solid-phase synthesis of an arylsulfone hydroxamate library.
pubmed:affiliation
Rhone Poulenc Rorer, Lead Discovery Department, Collegeville, PA 19426, USA. Jsalvino@aol.com
pubmed:publicationType
Journal Article