10937586

Source:http://linkedlifedata.com/resource/pubmed/id/10937586

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023516, umls-concept:C0025962, umls-concept:C0034693, umls-concept:C0035331, umls-concept:C0599946, umls-concept:C1285497, umls-concept:C1706144, umls-concept:C1880516, umls-concept:C1999216
pubmed:issue	9
pubmed:dateCreated	2000-8-15
pubmed:abstractText	The activity of protein kinase C (PKC), preferentially beta isoform of PKC, has been shown to be elevated in the diabetic retina. Recently, LY333531, a specific inhibitor of PKC-beta, has been reported to improve the decrease of retinal blood flow in early diabetes. Increased leukocyte entrapment has been suggested to be involved in blood flow disturbances in the early diabetic retina. This study was designed quantitatively to evaluate leukocyte entrapment in the retinal microcirculation of diabetic rats and the effect of LY333531 on leukocyte entrapment.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7703701
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acridine Orange, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Maleimides, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C, http://linkedlifedata.com/resource/pubmed/chemical/ruboxistaurin
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0146-0404
pubmed:author	pubmed-author:HondaYY, pubmed-author:KiryuJJ, pubmed-author:MiyamotoKK, pubmed-author:NishiwakiHH, pubmed-author:NonakoSS, pubmed-author:OguraYY, pubmed-author:TsujikawaAA, pubmed-author:YamashiroKK
pubmed:issnType	Print
pubmed:volume	41
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2702-6
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:10937586-Acridine Orange, pubmed-meshheading:10937586-Administration, Oral, pubmed-meshheading:10937586-Animals, pubmed-meshheading:10937586-Cell Adhesion, pubmed-meshheading:10937586-Cell Movement, pubmed-meshheading:10937586-Diabetes Mellitus, Experimental, pubmed-meshheading:10937586-Diabetic Retinopathy, pubmed-meshheading:10937586-Enzyme Inhibitors, pubmed-meshheading:10937586-Fluorescent Dyes, pubmed-meshheading:10937586-Fluorophotometry, pubmed-meshheading:10937586-Indoles, pubmed-meshheading:10937586-Leukocytes, pubmed-meshheading:10937586-Male, pubmed-meshheading:10937586-Maleimides, pubmed-meshheading:10937586-Microcirculation, pubmed-meshheading:10937586-Protein Kinase C, pubmed-meshheading:10937586-Rats, pubmed-meshheading:10937586-Rats, Long-Evans, pubmed-meshheading:10937586-Retinal Vessels
pubmed:year	2000
pubmed:articleTitle	PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats.
pubmed:affiliation	Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't