Linked Life Data

10936670

Source:http://linkedlifedata.com/resource/pubmed/id/10936670

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-1-26
pubmed:abstractText
Serum total sialic acid is a marker of the acute phase response. Elevated levels have also been associated with cardiovascular disease in the general Caucasian population and especially in Type 2 diabetic subjects. The purpose of this study was to estimate serum total sialic acid concentrations among Kuwaiti Type 2 diabetic subjects and to investigate its association with macro and microvascular diabetes-related complications in that population. Serum total sialic acid levels were estimated by an enzymatic spectro-photometric assay in two groups of subjects: (i) 358 Kuwaiti Type 2 diabetics (156 men and 202 women) referred for their annual evaluation to the specialised diabetic clinic at the main university teaching hospital in Kuwait, and (ii) 47 healthy age and sex matched non-diabetic Kuwaiti control population (13 men and 34 women). Serum sialic acid levels were significantly higher (P<0.001) among the diabetic patients (mean+/-S.D.) (81.2+/-13.2 mg/dl) compared to the non-diabetic controls (66.9+/-11.0 mg/dl). Kuwaiti diabetic women had significantly higher concentrations compared to diabetic men (85.2+/-12.1 vs. 75.9+/-13.0 mg/dl, P<0.001). Among the controls there was no significant gender difference in sialic acid levels of women, (68.3+/-11.6 mg/dl) versus men (63.2+/-8.2 mg/dl). The gender difference in the diabetic patients was unrelated to the degree of obesity. Significant correlations were found between serum total sialic acid concentrations and such cardiovascular risk factors as plasma levels of apolipoprotein B, low density lipoprotein cholesterol, triglycerides and uric acid in the diabetic subjects. Furthermore, there was a significant elevation in serum total sialic acid concentrations with increasing urinary albumin excretion, P<0.001, but not with retinopathy or neuropathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0168-8227
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10936670-Albuminuria, pubmed-meshheading:10936670-Biological Markers, pubmed-meshheading:10936670-Blood Glucose, pubmed-meshheading:10936670-Blood Pressure, pubmed-meshheading:10936670-Cardiovascular Diseases, pubmed-meshheading:10936670-Creatinine, pubmed-meshheading:10936670-Diabetes Complications, pubmed-meshheading:10936670-Diabetes Mellitus, pubmed-meshheading:10936670-Diabetes Mellitus, Type 2, pubmed-meshheading:10936670-Diabetic Angiopathies, pubmed-meshheading:10936670-Diabetic Retinopathy, pubmed-meshheading:10936670-Electrocardiography, pubmed-meshheading:10936670-Female, pubmed-meshheading:10936670-Hemoglobin A, Glycosylated, pubmed-meshheading:10936670-Humans, pubmed-meshheading:10936670-Kuwait, pubmed-meshheading:10936670-Lipids, pubmed-meshheading:10936670-Male, pubmed-meshheading:10936670-N-Acetylneuraminic Acid, pubmed-meshheading:10936670-Obesity, pubmed-meshheading:10936670-Risk Factors, pubmed-meshheading:10936670-Sex Characteristics, pubmed-meshheading:10936670-Triglycerides
pubmed:year
2000
pubmed:articleTitle
Relation of serum total sialic acid concentrations with diabetic complications and cardiovascular risk factors in Kuwaiti Type 2 diabetic patients.
pubmed:affiliation
Department of Medicine, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, 13110 Kuwait.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't