| pubmed-article:10933881 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C0009968 | lld:lifeskim |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C0205184 | lld:lifeskim |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C0068511 | lld:lifeskim |
| pubmed-article:10933881 | lifeskim:mentions | umls-concept:C1664784 | lld:lifeskim |
| pubmed-article:10933881 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10933881 | pubmed:dateCreated | 2000-9-12 | lld:pubmed |
| pubmed-article:10933881 | pubmed:abstractText | The lipophilic copper(I)-specific chelator neocuproine has been frequently used as an inhibitor of copper-mediated damage in biological systems. In this communication we report that the copper-mediated toxicity of 2,4,5-trichlorophenol is markedly potentiated by neocuproine at levels which are near-stoichiometric with respect to the copper concentration but is inhibited at higher concentrations. However, no potentiation was observed when neocuproine was substituted by bathocuproinedisulfonic acid, a negative charged ligand with essentially the same copper-binding characteristics as neocuproine. We found that the potentiation by neocuproine was due to the formation of a lipophilic copper complex, while the inhibition by bathocuproinedisulfonic acid was due to the formation of a hydrophilic one. Caution in the use of neocuproine to study copper-mediated toxicity is advised. | lld:pubmed |
| pubmed-article:10933881 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10933881 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933881 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10933881 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10933881 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:10933881 | pubmed:author | pubmed-author:ChevionMM | lld:pubmed |
| pubmed-article:10933881 | pubmed:author | pubmed-author:ZhuB ZBZ | lld:pubmed |
| pubmed-article:10933881 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10933881 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10933881 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10933881 | pubmed:volume | 380 | lld:pubmed |
| pubmed-article:10933881 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10933881 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10933881 | pubmed:pagination | 267-73 | lld:pubmed |
| pubmed-article:10933881 | pubmed:dateRevised | 2000-12-18 | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:meshHeading | pubmed-meshheading:10933881... | lld:pubmed |
| pubmed-article:10933881 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10933881 | pubmed:articleTitle | Copper-mediated toxicity of 2,4,5-trichlorophenol: biphasic effect of the copper(I)-specific chelator neocuproine. | lld:pubmed |
| pubmed-article:10933881 | pubmed:affiliation | Department of Cellular Biochemistry, Hebrew University-Hadassah Schools of Medicine and Dental Medicine, Jerusalem, 91120, Israel. benzhan.zhu@orst.edu | lld:pubmed |
| pubmed-article:10933881 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10933881 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10933881 | lld:pubmed |
