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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-9-12
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pubmed:abstractText |
The lipophilic copper(I)-specific chelator neocuproine has been frequently used as an inhibitor of copper-mediated damage in biological systems. In this communication we report that the copper-mediated toxicity of 2,4,5-trichlorophenol is markedly potentiated by neocuproine at levels which are near-stoichiometric with respect to the copper concentration but is inhibited at higher concentrations. However, no potentiation was observed when neocuproine was substituted by bathocuproinedisulfonic acid, a negative charged ligand with essentially the same copper-binding characteristics as neocuproine. We found that the potentiation by neocuproine was due to the formation of a lipophilic copper complex, while the inhibition by bathocuproinedisulfonic acid was due to the formation of a hydrophilic one. Caution in the use of neocuproine to study copper-mediated toxicity is advised.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4,5-trichlorophenol,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethyl Sulfoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrolines,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/bathocuproine sulfonate,
http://linkedlifedata.com/resource/pubmed/chemical/neocuproine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0003-9861
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
380
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-73
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:10933881-Catalase,
pubmed-meshheading:10933881-Chelating Agents,
pubmed-meshheading:10933881-Chlorophenols,
pubmed-meshheading:10933881-Copper,
pubmed-meshheading:10933881-Dimethyl Sulfoxide,
pubmed-meshheading:10933881-Drug Interactions,
pubmed-meshheading:10933881-Escherichia coli,
pubmed-meshheading:10933881-Ethanol,
pubmed-meshheading:10933881-Free Radical Scavengers,
pubmed-meshheading:10933881-Oxidation-Reduction,
pubmed-meshheading:10933881-Phenanthrolines,
pubmed-meshheading:10933881-Superoxide Dismutase
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pubmed:year |
2000
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pubmed:articleTitle |
Copper-mediated toxicity of 2,4,5-trichlorophenol: biphasic effect of the copper(I)-specific chelator neocuproine.
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pubmed:affiliation |
Department of Cellular Biochemistry, Hebrew University-Hadassah Schools of Medicine and Dental Medicine, Jerusalem, 91120, Israel. benzhan.zhu@orst.edu
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pubmed:publicationType |
Journal Article
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