| pubmed-article:10933496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0077401 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0077400 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10933496 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:10933496 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10933496 | pubmed:dateCreated | 2001-1-9 | lld:pubmed |
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| pubmed-article:10933496 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933496 | pubmed:abstractText | We present a model for the skeletal muscle troponin-C (TnC)/troponin-I (TnI) interaction, a critical molecular switch that is responsible for calcium-dependent regulation of the contractile mechanism. Despite concerted efforts by multiple groups for more than a decade, attempts to crystallize troponin-C in complex with troponin-I, or in the ternary troponin-complex, have not yet delivered a high-resolution structure. Many groups have pursued different experimental strategies, such as X-ray crystallography, NMR, small-angle scattering, chemical cross-linking, and fluorescent resonance energy transfer (FRET) to gain insights into the nature of the TnC/TnI interaction. We have integrated the results of these experiments to develop a model of the TnC/TnI interaction, using an atomic model of TnC as a scaffold. The TnI sequence was fit to each of two alternate neutron scattering envelopes: one that winds about TnC in a left-handed sense (Model L), and another that winds about TnC in a right-handed sense (Model R). Information from crystallography and NMR experiments was used to define segments of the models. Tests show that both models are consistent with available cross-linking and FRET data. The inhibitory region TnI(95-114) is modeled as a flexible beta-hairpin, and in both models it is localized to the same region on the central helix of TnC. The sequence of the inhibitory region is similar to that of a beta-hairpin region of the actin-binding protein profilin. This similarity supports our model and suggests the possibility of using an available profilin/actin crystal structure to model the TnI/actin interaction. We propose that the beta-hairpin is an important structural motif that communicates the Ca2+-activated troponin regulatory signal to actin. | lld:pubmed |
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| pubmed-article:10933496 | pubmed:language | eng | lld:pubmed |
