Linked Life Data

1093201

Source:http://linkedlifedata.com/resource/pubmed/id/1093201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1975-7-28
pubmed:abstractText
The ovulation-inducing and gonadotropin-releasing activities of [d-Leu-6, des-Gly NH2-10, Pro-ethylamide-9]-GnRH (II), were evaluated in rats, rabbits, and sheep. A sc dose of 3.4 ng/100 g body wt of the analog was equal to 160 ng/100 g body wt of GnRH in causing ovulation in the diestrous rat. At these dose levels, the integrated LH release was 1.9 times greater for the analog. Both the time of increase and maximum serum concentrations of LH were delayed after injection of the analog. Oral administration of II and GnRH to the proestrous rat resulted in an ED50 for ovulation of 0.92 and 54 mug/100 g body wt,respectively. Serum levels of LH and FSH were highly variable for the various treatment groups when both releasing substances were administered orally. The intense ovulating activity of II was also evident in the estrous rabbit as indicated by an activity 31 times greater than that of GnRH. Additionally, the analog was at least 50 times more active than GnRH in releasing LH in both the mid-luteal and anestrous ewe. From our experiments with the cycling rat it appears that the intense ovulation-inducing activity of II can be accounted for by the intrinsic LH-releasing activity of the nonapeptide, rather than by a prolonged release stimulus.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Conferences And Congresses, http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System, http://linkedlifedata.com/resource/pubmed/keyword/Follicle Stimulating..., http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins, http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins, Pituitary, http://linkedlifedata.com/resource/pubmed/keyword/Hormones, http://linkedlifedata.com/resource/pubmed/keyword/Luteinizing Hormone--analysis, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Pituitary Hormone Releasing Hormones, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1193-7
pubmed:dateRevised
2007-11-2
pubmed:otherAbstract
PIP: Ovulation and gonadotropin-releasing activity of D-Leu6, des-Gly NH2 10, Pro-ethylamide 9 -GnRH (38715) (2) were investigated in rats, rabbits and sheep. When given to the diestrous or proestrous rat, 2 was 47 and 59 times, respectively, more effective than pGlu-His-Trp-Ser-Tyr-Gly -Leu-Arg-Pro-Gly-NG2 (GnRH) in causing ovulation. The analog increased the number of ova shed at the higher dose levels in the diestrous rat (p less than .05) but neither peptide affected the number of ova recovered from proestrus rats. Generally, serum luteinizing hormone and follicle stimulating levels were related to the dose of the peptide. The integrated luteinizing hormone (LH) release was 1.9 times greater for the analog and the time of increase and maximum serum concentrations of LH were delayed after injection of the analog. The analog was at least 50 times more active than GnRH in releasing LH in both the midluteal and anestrous ewe. It appears that the intense ovulation-inducing activity of 2 can be accounted for by the intrinsic LH-releasing activity of the nonapeptide rather than by a prolonged release stimulus.
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Ovulation and gonadotropin-releasing activity of [p-LEU-6, DES-GLY NH2-10, pro-ethylamide-9] -GNRH.
pubmed:publicationType
Journal Article