Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1975-8-4
pubmed:abstractText
Bacteriophage T4 serine and proline transfer RNAs are derived from a common precursor RNA. This precusor RNA lacks -C-C-A sequences which could provide 3' termini for the mature transfer RNAs. We have deduced part of the pathway leading to the formation of the C-C-A sequences in the transfer RNAs by characterizing incompletely matured precursor molecules which accumulate during infection of mutant hosts that lack specific enzymes associated with transfer RNA metabolism. Maturation is initiated by the addition of -C-C-AOH to the 3' terminus of the precusor RNA through the combined actionof an unidentified nuclease and tRNA nucleotidyltransferase (EC 2.7.7.25). Precursor RNA molecules terminating in -C-C-AOH is serine transfer RNA and the second product is immature proline transfer RNA. The terminal steps leading to proline transfer RNA have not been fully delineated, but are known to involve the replacement of a -C-UOH sequence by -C-C-AOH.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4375202, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4519024, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4521813, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4560501, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4566457, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4579013, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4591184, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4591185, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4597453, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4609099, http://linkedlifedata.com/resource/pubmed/commentcorrection/1093182-4615176
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1491-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Three steps in conversion of large precursor RNA into serine and proline transfer RNAs.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.