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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0018792,
umls-concept:C0032821,
umls-concept:C0086376,
umls-concept:C0086418,
umls-concept:C0330390,
umls-concept:C0332281,
umls-concept:C0521116,
umls-concept:C1709866,
umls-concept:C1711351,
umls-concept:C2349975
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pubmed:issue |
6
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pubmed:dateCreated |
2000-8-31
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|
pubmed:abstractText |
A C825T polymorphism was recently identified in the human gene encoding for the beta(3)-subunit of heterotrimeric G proteins. The 825T allele is associated with a splice variant of Gbeta(3) and enhanced signal transduction. We hypothesized that patients carrying the 825T allele exhibit the modified Gbeta(3) phenotype. The resulting enhancement of signal transduction should be detectable in the Gbetagamma-dimer-mediated acetylcholine-stimulated K(+) current (I(K,ACh)).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
692-7
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10931811-Aged,
pubmed-meshheading:10931811-Alleles,
pubmed-meshheading:10931811-Calcium Channel Blockers,
pubmed-meshheading:10931811-Carbachol,
pubmed-meshheading:10931811-Cholinergic Agonists,
pubmed-meshheading:10931811-Dose-Response Relationship, Drug,
pubmed-meshheading:10931811-Electric Conductivity,
pubmed-meshheading:10931811-Female,
pubmed-meshheading:10931811-GTP-Binding Proteins,
pubmed-meshheading:10931811-Genotype,
pubmed-meshheading:10931811-Heart,
pubmed-meshheading:10931811-Heart Atria,
pubmed-meshheading:10931811-Heart Diseases,
pubmed-meshheading:10931811-Humans,
pubmed-meshheading:10931811-Male,
pubmed-meshheading:10931811-Middle Aged,
pubmed-meshheading:10931811-Myocardium,
pubmed-meshheading:10931811-Polymorphism, Genetic,
pubmed-meshheading:10931811-Potassium Channels,
pubmed-meshheading:10931811-Potassium Channels, Inwardly Rectifying
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pubmed:year |
2000
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pubmed:articleTitle |
G-Protein beta(3)-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currents.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, Medical Faculty, University of Technology, Dresden, Germany.
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pubmed:publicationType |
Journal Article
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