Linked Life Data

10929854

Source:http://linkedlifedata.com/resource/pubmed/id/10929854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-11-29
pubmed:abstractText
Actual implementation of probabilistic sensitivity analysis may lead to misleading or improper conclusions when it is applied to groups of patients rather than individual patients. The practice of combining first- and second-order simulations when modeling the outcome for a group of more than one patient yields an erroneous marginal distribution whenever the parameter values are randomly sampled for each patient while the results are presented as simulated means for the group of patients. This practice results in underrepresenting the second-order uncertainty. It may also distort the shape (especially the symmetry or extent of the tails) in the simulated distribution. As a result, it may lead to premature or incorrect conclusions of superiority. It may also result in inappropriate estimates of the value of further research to inform parameter values.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0272-989X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
314-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Representing both first- and second-order uncertainties by Monte Carlo simulation for groups of patients.
pubmed:affiliation
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. Elk@nmr.mgh.harvard.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't