Linked Life Data

10929225

Source:http://linkedlifedata.com/resource/pubmed/id/10929225

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-10-19
pubmed:abstractText
A lot of different endogenous and exogenous factors are accused to promote squamous cell carcinomas in the upper aerodigestive tract. Main risk factors are the chronic tobacco- and alcohol consumption. The fact, that many patients develop syn- or metachronic carcinomas in this area was first described by Slaughter et al. 1953 and explained with the phenomenon of field cancerisation. Concerning to this hypothesis the whole mucosa of the upper aerodigestive-tract is premalignant damaged. In our study the micronucleus-frequency was determined as a biomarker for the genetic injury to prove the fieldcancerisation on the cellular level at 159 people (control-group, abuser, patients with HNSCC). Our results confirm the hypothesis of fieldcancerisation of the mucosa of the upper aerodigestive-tract at strong tobacco- and alcohol consumers and patients with head and neck squamous cell carcinoma. Furthermore there is a highly statistically significant correlation between increasing micronucleus frequency and increasing tobacco abuse. As a final result of our study the micronucleus assay seems to be of good value to show a genotoxic damage in healthy mucosa at people with a high risk to develop HNSCC, but it's not usable to give any answer if and when such carcinomas arise.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0017-6192
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
444-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[Micronuclei as biological markers for the detection of local cancer transformation in the upper aerodigestive tract].
pubmed:affiliation
Klinik für Hals-, Nasen-, Ohrenkrankheiten, Gesichts- und Halschirurgie, Martin-Luther-Universität Halle-Wittenberg.
pubmed:publicationType
Journal Article, Biography, English Abstract, Historical Article