Linked Life Data

10928578

Source:http://linkedlifedata.com/resource/pubmed/id/10928578

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-1-11
pubmed:abstractText
Essential tremor (ET) is a common movement disorder that often becomes refractory to conventional pharmacologic management. Open-label studies suggest that gabapentin is efficacious for ET, but the results of controlled trials have been mixed. To determine the efficacy and tolerability of gabapentin in ET, we conducted a double-blind, placebo-controlled, cross-over trial evaluating two doses (1800 mg per day and 3600 mg per day; N = 25). Patients on other ET medications were maintained on their concurrent medications for 3 months prior to study initiation and throughout the study. Twenty patients (mean age, 69.9 +/- 6.1 yrs) completed the study. Overall, patient global assessments (p <0.05), observed tremor scores (p <0.005), water pouring scores (p <0.05), and activities of daily living scores (p <0.005) significantly improved. Accelerometry scores, spirographs, and investigator global impression scores did not improve. The results were similar for high and low doses. Statistical regression models did not demonstrate any significant predictors for response. Gabapentin may be effective in some cases of ET.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0885-3185
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
678-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10928578-Acetic Acids, pubmed-meshheading:10928578-Adult, pubmed-meshheading:10928578-Aged, pubmed-meshheading:10928578-Aged, 80 and over, pubmed-meshheading:10928578-Amines, pubmed-meshheading:10928578-Antiparkinson Agents, pubmed-meshheading:10928578-Cross-Over Studies, pubmed-meshheading:10928578-Cyclohexanecarboxylic Acids, pubmed-meshheading:10928578-Dose-Response Relationship, Drug, pubmed-meshheading:10928578-Double-Blind Method, pubmed-meshheading:10928578-Essential Tremor, pubmed-meshheading:10928578-Female, pubmed-meshheading:10928578-Humans, pubmed-meshheading:10928578-Male, pubmed-meshheading:10928578-Middle Aged, pubmed-meshheading:10928578-Neurologic Examination, pubmed-meshheading:10928578-Treatment Outcome, pubmed-meshheading:10928578-gamma-Aminobutyric Acid
pubmed:year
2000
pubmed:articleTitle
Gabapentin for essential tremor: a multiple-dose, double-blind, placebo-controlled trial.
pubmed:affiliation
Baylor College of Medicine, Houston, Texas, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't