Linked Life Data

10928057

Source:http://linkedlifedata.com/resource/pubmed/id/10928057

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3A
pubmed:dateCreated
2000-8-17
pubmed:abstractText
Changes in the relative mRNA levels of phosphate-activated glutaminase (PAG) and glutamine synthetase (GS) in the liver and kidney of mice bearing a highly malignant strain of Ehrlich ascites tumor cells were determined at different days after tumor transplantation. Kidney glutaminase mRNA steadily increased, reaching maximum values at day 10 of tumor growth, while those of glutamine synthetase did not change, resulting in a sustained decrease of the GS/PAG ratio in the kidneys of tumor-bearing animals compared with controls. However, the GS/PAG ratio in the liver significantly increased, mainly due to a strong decrease in PAG, whereas GS mRNA levels remained almost unaffected. These results, combined with those previously reported on enzymatic activities and glutamine concentrations in the host-tumor system, suggest a long-term regulation of the host glutaminase enzymes in order to increase the circulating glutamine levels needed for tumor growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1463-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Changes in mRNAs for enzymes of glutamine metabolism in the tumor-bearing mouse.
pubmed:affiliation
Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't