Linked Life Data

1092576

Source:http://linkedlifedata.com/resource/pubmed/id/1092576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1975-7-31
pubmed:abstractText
A more effective influenza virus vaccine must be capable of inducing a greater degree of protection against the disease while causing fewer unwanted side effects. If the vaccine is an attenuated one, it should not be transmissible unless it can incontrovertably be shown to be genetically stable and not mutate to a more virulent form. One approach for producing an attenuated strain has been to select for horse serum inhibitor resistance. Such a strain (ANN strain, Recherche et Industrie Thérapeutique) was tested for the above characteristics. The vaccine (containing 10-7 50 percent egg infectious doses) and placebo was administered in a double-blind fashion to 37 volunteers in 2 doses 2-3 weeks apart. Volunteers were housed so that a vaccinee and control shared a room for 4 days following immunization. The only side effects noted were mild rhinorrhea and sore throat in 3 vaccinees. There was no evidence of vaccine virus having been transmitted from a vaccinee to a control individual.A 4-fold or greater rise in serum antibody was noted in 13/19 vaccinees following either the 1st or 2nd dose. Only 1/18 controls showed such a rise. A similar nasal antibody rise was noted in 15/19 and 1/18 of the vaccine and placebo groups respectively. Following virulent challenge 7 of 18 in the control group, and 1 of 19 vaccinees, became ill.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-53
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
An attenuated influenza virus vaccine: reactogenicity, transmissibility, immunogenicity and protective efficacy.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Controlled Clinical Trial