Linked Life Data

1092575

Source:http://linkedlifedata.com/resource/pubmed/id/1092575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1975-7-31
pubmed:abstractText
Assessment of influenza vaccines by serological conversion rates or by protection against artificial challenge in animals or man give only a preliminary and indirect guide to their expected efficiency in controlling the natural epidemic disease. Field trials are essential but demand careful advance planning and control before meaningful results can be obtained. This paper reviews critically the various attempts that have been made to establish an ideal trial procedure to overcome the many inherent difficulties in studying 'wild' influenza. Vaccines of appropriate antigenic content can prevent influenza in 75 percent or more of recipients for up to a year, and can decrease the severity and duration of the disease in those who do succumb. Attack rates can be reduced even in epidemics occurring within 8-14 days of vaccination. If a high proportion of a population is vaccinated, infection rates in the unvaccinated in the same environment may fall. The desirability of vaccinating (a) only high risk groups or (b) entire open population or (c) school children is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-94
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Assessment of the efficacy of influenza vaccines against natural challenge.
pubmed:publicationType
Journal Article, Clinical Trial