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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-9-14
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pubmed:abstractText |
IL-18 is a proinflammatory cytokine that enhances innate and specific Th1 immune responses. During microbial infections, IL-18 is produced by activated macrophages. IL-18 exerts its effects in synergy with IFN-alpha or IL-12 to induce IFN-gamma. Here we show that in human NK and T cells IFN-alpha and IL-12 strongly up-regulate mRNA expression of the IL-18R components, accessory protein-like (AcPL) and IL-1R-related protein (IL-1Rrp). In addition, IFN-alpha enhanced the expression of MyD88, an adaptor molecule involved in IL-18 signaling. Pretreatment of T cells with IFN-alpha or IL-12 enhanced IL-18-induced NF-kappaB activation and sensitized the cells to respond to lower concentrations of IL-18. AcPL and IL-1Rrp genes were strongly expressed in T cells polarized with IL-12, whereas in IL-4-polarized cells these genes were expressed at very low levels, indicating that AcPL and IL-1Rrp genes are preferentially expressed in Th1 cells. In conclusion, the results suggest that IFN-alpha and IL-12 enhance innate as well as Th1 immune response by inducing IL-18R expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/IL18R1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL18RAP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18 Receptor alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18 Receptor beta Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/MYD88 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-18
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1933-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10925275-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10925275-Adjuvants, Immunologic,
pubmed-meshheading:10925275-Antigens, Differentiation,
pubmed-meshheading:10925275-Cell Line,
pubmed-meshheading:10925275-Cell Polarity,
pubmed-meshheading:10925275-Cells, Cultured,
pubmed-meshheading:10925275-DNA,
pubmed-meshheading:10925275-Drug Synergism,
pubmed-meshheading:10925275-Gene Expression Regulation,
pubmed-meshheading:10925275-Humans,
pubmed-meshheading:10925275-Interferon-alpha,
pubmed-meshheading:10925275-Interferon-gamma,
pubmed-meshheading:10925275-Interleukin-12,
pubmed-meshheading:10925275-Interleukin-18,
pubmed-meshheading:10925275-Interleukin-18 Receptor alpha Subunit,
pubmed-meshheading:10925275-Interleukin-18 Receptor beta Subunit,
pubmed-meshheading:10925275-Killer Cells, Natural,
pubmed-meshheading:10925275-Lymphocyte Activation,
pubmed-meshheading:10925275-Myeloid Differentiation Factor 88,
pubmed-meshheading:10925275-NF-kappa B,
pubmed-meshheading:10925275-Protein Binding,
pubmed-meshheading:10925275-Protein Biosynthesis,
pubmed-meshheading:10925275-Proteins,
pubmed-meshheading:10925275-RNA, Messenger,
pubmed-meshheading:10925275-Receptors, Immunologic,
pubmed-meshheading:10925275-Receptors, Interleukin,
pubmed-meshheading:10925275-Receptors, Interleukin-1,
pubmed-meshheading:10925275-Receptors, Interleukin-12,
pubmed-meshheading:10925275-Receptors, Interleukin-18,
pubmed-meshheading:10925275-T-Lymphocytes
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pubmed:year |
2000
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pubmed:articleTitle |
IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.
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pubmed:affiliation |
Department of Virology, National Public Health Institute, Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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