|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2000-8-31
|
|
pubmed:abstractText |
Previously, we demonstrated that hypertonic saline solution (HTS) and endotoxin (lipopolysaccharide [LPS]) induce prostacyclin (PGI(2)) production in human endothelial cells. Here, we hypothesized that HTS and LPS may induce PGI(2) production by increasing cyclooxygenase (COX) expression. We further examined the activation of p38 and extracellular signal-regulated kinases (ERK) and questioned whether these transduction cascades might mediate COX expression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(4-fluorophenyl)-2-(4-hydroxypheny...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epoprostenol,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Saline Solution, Hypertonic
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0039-6060
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
128
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
198-205
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10922992-Cell Survival,
pubmed-meshheading:10922992-Cells, Cultured,
pubmed-meshheading:10922992-Cyclooxygenase 2,
pubmed-meshheading:10922992-Endothelium, Vascular,
pubmed-meshheading:10922992-Enzyme Inhibitors,
pubmed-meshheading:10922992-Epoprostenol,
pubmed-meshheading:10922992-Escherichia coli,
pubmed-meshheading:10922992-Flavonoids,
pubmed-meshheading:10922992-Humans,
pubmed-meshheading:10922992-Imidazoles,
pubmed-meshheading:10922992-Isoenzymes,
pubmed-meshheading:10922992-Kinetics,
pubmed-meshheading:10922992-Lipopolysaccharides,
pubmed-meshheading:10922992-Membrane Proteins,
pubmed-meshheading:10922992-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:10922992-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:10922992-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10922992-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10922992-Pyridines,
pubmed-meshheading:10922992-Saline Solution, Hypertonic,
pubmed-meshheading:10922992-Umbilical Veins
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Hypertonic saline solution induces prostacyclin production by increasing cyclooxygenase-2 expression.
|
|
pubmed:affiliation |
Department of Surgery, University of Washington, Seattle 98104, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
