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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-8-29
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 [Allikmets et al. (1995) Mamm. Genome 6, 111-117]. The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
478
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10922475-ATP-Binding Cassette Transporters,
pubmed-meshheading:10922475-Amino Acid Motifs,
pubmed-meshheading:10922475-Amino Acid Sequence,
pubmed-meshheading:10922475-Animals,
pubmed-meshheading:10922475-Bone Marrow,
pubmed-meshheading:10922475-Cell Line,
pubmed-meshheading:10922475-Chromosomes, Human, Pair 1,
pubmed-meshheading:10922475-Chromosomes, Human, Pair 15,
pubmed-meshheading:10922475-Cloning, Molecular,
pubmed-meshheading:10922475-Gene Expression Profiling,
pubmed-meshheading:10922475-Humans,
pubmed-meshheading:10922475-In Situ Hybridization, Fluorescence,
pubmed-meshheading:10922475-Intracellular Membranes,
pubmed-meshheading:10922475-Mitochondria,
pubmed-meshheading:10922475-Molecular Sequence Data,
pubmed-meshheading:10922475-Phylogeny,
pubmed-meshheading:10922475-Physical Chromosome Mapping,
pubmed-meshheading:10922475-Protein Sorting Signals,
pubmed-meshheading:10922475-Pseudogenes,
pubmed-meshheading:10922475-RNA, Messenger,
pubmed-meshheading:10922475-Sequence Alignment,
pubmed-meshheading:10922475-Transfection
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pubmed:year |
2000
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pubmed:articleTitle |
M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein.
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pubmed:affiliation |
BC Cancer Research Centre, British Columbia Cancer Agency, University of British Columbia, 601 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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