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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-12-5
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pubmed:abstractText |
Nitric oxide (NO) has been recently implicated as a powerful inhibitor of immune responses during allograft rejection, and some autoimmune and infectious diseases. We previously showed that one potential regulatory effect of NO is inhibition of IFNgamma-stimulated expression of Class II MHC on macrophages. Activation of this gene is mediated by the "Class II TransActivator" (CIITA). We now ask whether NO inhibits CIITA and thus the family of genes regulated by CIITA--Class II MHC, Ii, and H-2M. The latter two genes participate in antigen processing and formation of the cell-surface peptide-Class II MHC complex.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/MHC class II transactivator protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/S-nitro-N-acetylpenicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/invariant chain
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0360-3997
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
431-45
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10921507-Animals,
pubmed-meshheading:10921507-Antigen Presentation,
pubmed-meshheading:10921507-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:10921507-Cell Line,
pubmed-meshheading:10921507-Female,
pubmed-meshheading:10921507-Gene Expression Regulation,
pubmed-meshheading:10921507-Genes, MHC Class II,
pubmed-meshheading:10921507-Histocompatibility Antigens Class II,
pubmed-meshheading:10921507-Interferon-gamma,
pubmed-meshheading:10921507-Macrophages, Peritoneal,
pubmed-meshheading:10921507-Mice,
pubmed-meshheading:10921507-Mice, Inbred C3H,
pubmed-meshheading:10921507-Nitric Oxide,
pubmed-meshheading:10921507-Nitric Oxide Donors,
pubmed-meshheading:10921507-Nuclear Proteins,
pubmed-meshheading:10921507-Penicillamine,
pubmed-meshheading:10921507-Polymerase Chain Reaction,
pubmed-meshheading:10921507-RNA, Messenger,
pubmed-meshheading:10921507-Recombinant Proteins,
pubmed-meshheading:10921507-Trans-Activators,
pubmed-meshheading:10921507-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Nitric oxide inhibits INFgamma-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes--class II MHC, Ii and H-2M. Class II TransActivator.
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pubmed:affiliation |
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8856, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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