Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-3-1
pubmed:abstractText
The genes encoding hepatocyte nuclear factor 3 (HNF3) proteins play a pivotal role in the regulation of metabolism and in the differentiation of metabolic tissues such as the pancreas and liver. HNF3 transcription factors bind to cis-regulatory elements in hundreds of genes encoding gluconeogenic and glycolytic enzymes, serum proteins and hormones. Genetic analysis in mice has shown that HNF3 beta is necessary for the development of the foregut endoderm, from which the liver and pancreas arise. HNF3 alpha is required for the full activation of glucagon in the pancreas, whereas HNF3 gamma induces the activation of gluconeogenic enzymes to prevent hypoglycemia during fasting.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1043-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism.
pubmed:affiliation
Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104-6145, USA. kaestner@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review