Source:http://linkedlifedata.com/resource/pubmed/id/10920211
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-9-25
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pubmed:abstractText |
Children with osteogenesis imperfecta (OI) type III and type IV were studied using a (42)Ca stable isotope technique. Serum dilution kinetics of (42)Ca were studied pre- and post-growth hormone (GH) treatment in 9 OI III (age range 5-9 years) and 8 OI IV patients (age range 5-12 years). Each subject was studied twice: at baseline and following GH therapy (range 1-1.5 years). Isotopic enrichments of (42)Ca were followed over 7 days using thermal ionization mass spectrometry. A binding site model, which describes reversible and irreversible binding of calcium (Ca) ions to postulated short- and long-term binding sites in bone, was used to analyze the kinetic data. In type III patients, GH treatment (1) increased the fraction of short-term binding sites, theta (0.777 +/- 0.112 versus 0.877 +/- 0.05, respectively; P = 0.034); (2) increased the apparent half-life of a Ca ion attached to the long-term binding site by 76% (P = 0. 009); (3) although not statistically significant (P = 0.098), a trend toward an increased growth rate was observed with increasing change in theta (Deltatheta); (4) patients experienced a 75% increase in growth rate during the first 6 months of treatment. In type IV patients, GH treatment increased the apparent half-life of a Ca ion attached to the long-term binding site by 83% (P = 0.048), however, no trend toward an increased growth rate was observed with increasing Deltatheta in these patients. These significant changes in Ca binding to bone may influence growth in type III patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0171-967X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-100
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10920211-Bone Development,
pubmed-meshheading:10920211-Bone and Bones,
pubmed-meshheading:10920211-Calcium,
pubmed-meshheading:10920211-Calcium Isotopes,
pubmed-meshheading:10920211-Child,
pubmed-meshheading:10920211-Child, Preschool,
pubmed-meshheading:10920211-Human Growth Hormone,
pubmed-meshheading:10920211-Humans,
pubmed-meshheading:10920211-Indicator Dilution Techniques,
pubmed-meshheading:10920211-Mass Spectrometry,
pubmed-meshheading:10920211-Osteogenesis Imperfecta
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pubmed:year |
2000
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pubmed:articleTitle |
Calcium kinetics in children with osteogenesis imperfecta type III and IV: pre- and post-growth hormone therapy.
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pubmed:affiliation |
National Institute of Child Health and Human Development, National Institutes of Health, Laboratory of Cellular and Molecular Biophysics, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
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