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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-9-12
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pubmed:abstractText |
Estrogen receptor modulators (SERMs) are "designer drugs" that exert estrogen-like actions in some cells but not in others. We examined the effects of the SERMs LY-117018 (an analog of raloxifene) and tamoxifen on mesangial cells synthesis of type I and type IV collagen. We found that LY-117018 and tamoxifen suppressed mesangial cell type IV collagen gene transcription and type IV collagen protein synthesis in a dose-dependent manner, with a potency identical to that of estradiol. Type I collagen synthesis was also suppressed by LY-117018 in a dose-dependent manner with a potency identical to that of estradiol but greater than that of tamoxifen. Genistein, which selectively binds to estrogen receptor-beta in nanomolar concentrations, suppressed type I and type IV collagen synthesis, suggesting that estrogen receptor-beta mediates the effects of estrogen on collagen synthesis. Because matrix accumulation is central to the development of glomerulosclerosis, second-generation SERMs may prove clinically useful in ameliorating progressive renal disease without the adverse effects of estrogen on reproductive tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/LY 117018,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Selective Estrogen Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1931-857X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F309-18
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
pubmed-meshheading:10919851-Angiotensin II,
pubmed-meshheading:10919851-Animals,
pubmed-meshheading:10919851-Cell Line, Transformed,
pubmed-meshheading:10919851-Collagen,
pubmed-meshheading:10919851-Endothelin-1,
pubmed-meshheading:10919851-Estrogen Receptor beta,
pubmed-meshheading:10919851-Estrogens,
pubmed-meshheading:10919851-Glomerular Mesangium,
pubmed-meshheading:10919851-Mice,
pubmed-meshheading:10919851-Mice, Inbred Strains,
pubmed-meshheading:10919851-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10919851-Pyrrolidines,
pubmed-meshheading:10919851-Receptors, Estrogen,
pubmed-meshheading:10919851-Selective Estrogen Receptor Modulators,
pubmed-meshheading:10919851-Tamoxifen,
pubmed-meshheading:10919851-Thiophenes,
pubmed-meshheading:10919851-Transcription, Genetic,
pubmed-meshheading:10919851-Transcription Factor AP-1,
pubmed-meshheading:10919851-Transforming Growth Factor beta,
pubmed-meshheading:10919851-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
Selective estrogen receptor modulators suppress mesangial cell collagen synthesis.
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pubmed:affiliation |
Nephrology Division, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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