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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-9-15
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pubmed:abstractText |
A number of 4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols 2a-n were synthesized and tested in vivo for anti-inflammatory and analgesic activities and in vitro for platelet anti-aggregating activity. Dimethylaminoderivatives 2b, e, g showed good analgesic activity; almost all of them had strong platelet anti-aggregating properties at a final concentration of 1 x 10(-3) M; pyrazoles 2c, d, f-h showed weak anti-inflammatory activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-827X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10919086-Analgesics,
pubmed-meshheading:10919086-Animals,
pubmed-meshheading:10919086-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:10919086-Butanols,
pubmed-meshheading:10919086-Carrageenan,
pubmed-meshheading:10919086-Edema,
pubmed-meshheading:10919086-Humans,
pubmed-meshheading:10919086-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10919086-Mice,
pubmed-meshheading:10919086-Pain Measurement,
pubmed-meshheading:10919086-Platelet Aggregation,
pubmed-meshheading:10919086-Platelet Aggregation Inhibitors,
pubmed-meshheading:10919086-Pyrazoles,
pubmed-meshheading:10919086-Rats
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pubmed:year |
2000
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pubmed:articleTitle |
4-Dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols: synthesis and evaluation of analgesic, anti-inflammatory and platelet anti-aggregating activities.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Genova, Italy. menozzi@unige.it
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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