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pubmed:abstractText |
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.
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pubmed:affiliation |
National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Room 8N805, Building 38A, Bethesda, MD 20894, USA. Edwards@ncbi.nlm.nih.gov
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