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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-8-25
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pubmed:abstractText |
The p53 tumor suppressor gene is the most commonly mutated gene in human cancer, and mutations arise in a wide variety of tumor types. Wild-type p53 functions as a regulator of apoptosis, so mutations in the p53 gene are generally associated with aggressive tumors and a poor prognosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0098-1532
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-103
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10918230-Adolescent,
pubmed-meshheading:10918230-Adult,
pubmed-meshheading:10918230-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10918230-Blotting, Southern,
pubmed-meshheading:10918230-Cell Line,
pubmed-meshheading:10918230-Child,
pubmed-meshheading:10918230-Child, Preschool,
pubmed-meshheading:10918230-Combined Modality Therapy,
pubmed-meshheading:10918230-Exons,
pubmed-meshheading:10918230-Gene Amplification,
pubmed-meshheading:10918230-Humans,
pubmed-meshheading:10918230-Infant,
pubmed-meshheading:10918230-Mutation,
pubmed-meshheading:10918230-Neoplasm Proteins,
pubmed-meshheading:10918230-Nuclear Proteins,
pubmed-meshheading:10918230-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:10918230-Prognosis,
pubmed-meshheading:10918230-Proto-Oncogene Proteins,
pubmed-meshheading:10918230-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:10918230-Rhabdomyosarcoma,
pubmed-meshheading:10918230-Tumor Suppressor Protein p53
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pubmed:year |
2000
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pubmed:articleTitle |
P53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines.
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pubmed:affiliation |
Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. linda.harris@stjude.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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