rdf:type |
|
lifeskim:mentions |
umls-concept:C0002915,
umls-concept:C0005854,
umls-concept:C0011209,
umls-concept:C0026336,
umls-concept:C0033487,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0059874,
umls-concept:C0205195,
umls-concept:C0235032,
umls-concept:C0392747,
umls-concept:C0729502,
umls-concept:C1521801,
umls-concept:C1554963,
umls-concept:C2349975
|
pubmed:issue |
1
|
pubmed:dateCreated |
2001-1-3
|
pubmed:abstractText |
Osmotic blood-brain barrier disruption (BBBD) increases brain and brain tumor delivery of chemotherapeutic agents, which results in increased efficacy against brain tumors. We previously noted that the use of propofol anesthesia for BBBD increased the percentage of successful disruptions, resulting in delivery of increased amounts of chemotherapeutic drugs. This study evaluated the neurotoxicity of combination chemotherapeutic administration with this enhanced delivery system.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0148-396X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
199-207
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:10917363-Anesthesia, General,
pubmed-meshheading:10917363-Anesthetics, Intravenous,
pubmed-meshheading:10917363-Animals,
pubmed-meshheading:10917363-Antineoplastic Agents,
pubmed-meshheading:10917363-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10917363-Blood-Brain Barrier,
pubmed-meshheading:10917363-Disease Models, Animal,
pubmed-meshheading:10917363-Etoposide,
pubmed-meshheading:10917363-Female,
pubmed-meshheading:10917363-Neurotoxicity Syndromes,
pubmed-meshheading:10917363-Organophosphorus Compounds,
pubmed-meshheading:10917363-Propofol,
pubmed-meshheading:10917363-Rats,
pubmed-meshheading:10917363-Rats, Long-Evans
|
pubmed:year |
2000
|
pubmed:articleTitle |
Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model.
|
pubmed:affiliation |
Department of Neurology, Oregon Health Sciences University, and Veterans Administration Medical Center, Portland, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|