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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-17
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pubmed:abstractText |
A variety of factors have been identified that regulate angiogenesis, including the CXC chemokine family. The CXC chemokines are a unique family of cytokines for their ability to behave in a disparate manner in the regulation of angiogenesis. CXC chemokines have four highly conserved cysteine amino acid residues, with the first two cysteine amino acid residues separated by one non-conserved amino acid residue (i.e., CXC). A second structural domain within this family determines their angiogenic potential. The NH2 terminus of the majority of the CXC chemokines contains three amino acid residues (Glu-Leu-Arg: the ELR motif), which precedes the first cysteine amino acid residue of the primary structure of these cytokines. Members that contain the ELR motif (ELR+) are potent promoters of angiogenesis. In contrast, members that are inducible by interferons and lack the ELR motif (ELR-) are potent inhibitors of angiogenesis. This difference in angiogenic activity may impact on the pathogenesis of a variety of disorders.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10914483-Amino Acid Motifs,
pubmed-meshheading:10914483-Angiogenesis Inhibitors,
pubmed-meshheading:10914483-Animals,
pubmed-meshheading:10914483-Arthritis, Rheumatoid,
pubmed-meshheading:10914483-Chemokine CXCL10,
pubmed-meshheading:10914483-Chemokines, CXC,
pubmed-meshheading:10914483-Chronic Disease,
pubmed-meshheading:10914483-Fibrosis,
pubmed-meshheading:10914483-Humans,
pubmed-meshheading:10914483-Inflammation,
pubmed-meshheading:10914483-Interleukin-8,
pubmed-meshheading:10914483-Mice,
pubmed-meshheading:10914483-Mice, Nude,
pubmed-meshheading:10914483-Neoplasm Proteins,
pubmed-meshheading:10914483-Neoplasms,
pubmed-meshheading:10914483-Neovascularization, Pathologic,
pubmed-meshheading:10914483-Neovascularization, Physiologic,
pubmed-meshheading:10914483-Pulmonary Fibrosis,
pubmed-meshheading:10914483-Receptors, Chemokine,
pubmed-meshheading:10914483-Structure-Activity Relationship
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pubmed:year |
2000
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pubmed:articleTitle |
CXC chemokines in angiogenesis.
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pubmed:affiliation |
Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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