Source:http://linkedlifedata.com/resource/pubmed/id/10913340
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2000-8-24
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| pubmed:databankReference | |
| pubmed:abstractText |
The fibroblast growth factors (FGFs) play important roles in morphogenesis, angiogenesis, tissue remodeling, and carcinogenesis. Human FGF-20 has been cloned and characterized in this study. FGF-20 encodes a 211-amino-acid polypeptide with the FGF-core domain. A strong hydrophobic region was found in the FGF-core domain of FGF-20; however, no typical N-terminal signal sequence was found in FGF-20, just as in FGF-9 and FGF-16. Total amino acid identities are as follows: FGF-20 vs FGF-9, 71.6%; FGF-20 vs FGF-16, 66.2%; FGF-9 vs FGF-16, 72.4%. Phylogenic analysis indicated that FGF-20, FGF-9, and FGF-16 constitute a subfamily among the FGF family. FGF-20 mRNA of 2.4 kb in size was detected in colon cancer cell line SW480 by Northern blot analysis. Lower levels of FGF-20 mRNA were detected in human fetal tissues and primary cancers by cDNA-PCR. The nucleotide sequence of FGF-20 cDNA is split into three parts in the human genome sequence of the chromosome 8p21.3-p22 region (Accession No. AB020858). These results indicate that the FGF-20 gene, located on human chromosome 8p21.3-p22, consists of three exons. Compared with the nucleotide sequence of FGF-20 cDNA determined in this study, one nucleotide deletion and one nucleotide substitution in the putative coding region were identified in human genome sequence AB020858.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/fibroblast growth factor 20, Xenopus
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0006-291X
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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| pubmed:issnType |
Print
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| pubmed:day |
2
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| pubmed:volume |
274
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
337-43
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10913340-Alternative Splicing,
pubmed-meshheading:10913340-Animals,
pubmed-meshheading:10913340-Base Sequence,
pubmed-meshheading:10913340-Blotting, Northern,
pubmed-meshheading:10913340-Breast Neoplasms,
pubmed-meshheading:10913340-Cell Line,
pubmed-meshheading:10913340-Chromosomes, Human, Pair 8,
pubmed-meshheading:10913340-Cloning, Molecular,
pubmed-meshheading:10913340-Colonic Neoplasms,
pubmed-meshheading:10913340-DNA, Complementary,
pubmed-meshheading:10913340-Fibroblast Growth Factors,
pubmed-meshheading:10913340-Humans,
pubmed-meshheading:10913340-Molecular Sequence Data,
pubmed-meshheading:10913340-Phylogeny,
pubmed-meshheading:10913340-Polymerase Chain Reaction,
pubmed-meshheading:10913340-RNA, Messenger,
pubmed-meshheading:10913340-Sequence Analysis, Protein,
pubmed-meshheading:10913340-Sequence Homology, Amino Acid,
pubmed-meshheading:10913340-Stomach Neoplasms,
pubmed-meshheading:10913340-Xenopus,
pubmed-meshheading:10913340-Xenopus Proteins
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| pubmed:year |
2000
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| pubmed:articleTitle |
Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.
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| pubmed:affiliation |
Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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