Source:http://linkedlifedata.com/resource/pubmed/id/10912844
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2000-8-30
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| pubmed:abstractText |
We determined bone density and metabolism in 46 patients (35 males, 11 females) who had undergone liver transplantation 1-48 months previously. Twenty-one patients were then followed for the next 24 months. At each visit, blood and urine samples for bone and liver metabolism parameters, as well as spinal and femoral dual-energy X-ray absorptiometry (DXA) scans, were obtained. Basal spinal and femoral density was low (p < 0.001). Patients with pre-transplant cholestatic diseases had lower spinal density than all the other subjects (p <0.05) and the cumulative methylprednisolone intake was an independent negative predictor of total hip density (p < 0.02). At baseline, urinary hydroxyproline and N-telopeptide were at the upper normal level and decreased only after 24 months of follow-up (p < 0.05). During the first year of follow-up, femoral density decreased (p < 0.05) and a partial recovery was observed for both spine and femur after 24 months. After 12 months, femoral bone density was negatively associated with serum cyclosporin A levels (p < 0.005) and cumulative methylprednisolone intake (p < 0.05), while the percent decrease in spinal density after the first 12 months was negatively predicted by mean daily methylprednisolone intake (p < 0.05). In patients with pre-transplant cholestatic diseases, femoral and spinal density increased after the first (p < 0.05) and second year (p < 0.05), respectively. In patients with previous post-necrotic cirrhosis, femoral density decreased after 12 months (p<0.05) and was still lower than baseline after 24 months (p < 0.05). However, at the end of the study the cumulative percentage of femoral neck osteoporosis was 43%. In conclusion, an elevated prevalence of spinal and femoral osteoporosis is present even many years after liver transplantation, with immunosuppressive treatment and pre-transplant liver disease being the most important pathogenetic factors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0937-941X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
11
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
417-24
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10912844-Adult,
pubmed-meshheading:10912844-Biological Markers,
pubmed-meshheading:10912844-Bone Density,
pubmed-meshheading:10912844-Bone and Bones,
pubmed-meshheading:10912844-Cross-Sectional Studies,
pubmed-meshheading:10912844-Female,
pubmed-meshheading:10912844-Femur,
pubmed-meshheading:10912844-Follow-Up Studies,
pubmed-meshheading:10912844-Humans,
pubmed-meshheading:10912844-Immunosuppressive Agents,
pubmed-meshheading:10912844-Liver Diseases,
pubmed-meshheading:10912844-Liver Transplantation,
pubmed-meshheading:10912844-Lumbar Vertebrae,
pubmed-meshheading:10912844-Male,
pubmed-meshheading:10912844-Middle Aged,
pubmed-meshheading:10912844-Osteoporosis,
pubmed-meshheading:10912844-Postoperative Complications,
pubmed-meshheading:10912844-Time Factors
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Long-term persistence of low bone density in orthotopic liver transplantation.
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| pubmed:affiliation |
Department of Medical and Surgical Sciences, University of Padua and National Research Council, Centre for Aging Studies of Padua, Italy. giannini@ux1.unipd.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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