Source:http://linkedlifedata.com/resource/pubmed/id/10912756
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6 Pt 1
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| pubmed:dateCreated |
2000-11-2
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| pubmed:abstractText |
In Milan hypertensive rats, a variant in the alpha-adducin gene has been shown to account for approximately 50% of the interindividual variation in blood pressure levels between these animals and their normotensive counterparts. Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity. On the basis of these observations, we investigated variation within or near the human alpha-adducin gene for linkage and association with a locus influencing blood pressure levels in 281 nuclear families (774 siblings aged 5 to 37 years; 380 parents aged 26 to 57 years), selected from the white population of Rochester, Minnesota, without regard to health. Sib pair linkage analyses (n = 852 sibling pairs) using a dinucleotide repeat marker (D4S43) that maps approximately 660 kb from the alpha-adducin gene provided no evidence of linkage between this marker locus and a locus influencing systolic, diastolic, or mean blood pressure levels. Allele frequencies for the Gly-460-Trp polymorphism were similar to those reported in other white populations (Gly = 0.812, Trp = 0.188); however, this polymorphism was not associated with any measure of blood pressure level in either parents or siblings. Therefore, variation within the alpha-adducin gene does not appear to have a major influence on measures of blood pressure in white families from Rochester, Minnesota.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/adducin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0895-7061
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
699-703
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:10912756-Adolescent,
pubmed-meshheading:10912756-Adult,
pubmed-meshheading:10912756-Alleles,
pubmed-meshheading:10912756-Blood Pressure,
pubmed-meshheading:10912756-Calmodulin-Binding Proteins,
pubmed-meshheading:10912756-Child,
pubmed-meshheading:10912756-Child, Preschool,
pubmed-meshheading:10912756-Cytoskeletal Proteins,
pubmed-meshheading:10912756-DNA,
pubmed-meshheading:10912756-DNA Primers,
pubmed-meshheading:10912756-Female,
pubmed-meshheading:10912756-Gene Frequency,
pubmed-meshheading:10912756-Genetic Linkage,
pubmed-meshheading:10912756-Genetic Markers,
pubmed-meshheading:10912756-Genotype,
pubmed-meshheading:10912756-Humans,
pubmed-meshheading:10912756-Hypertension,
pubmed-meshheading:10912756-Male,
pubmed-meshheading:10912756-Middle Aged,
pubmed-meshheading:10912756-Nuclear Family,
pubmed-meshheading:10912756-Polymerase Chain Reaction,
pubmed-meshheading:10912756-Polymorphism, Genetic,
pubmed-meshheading:10912756-Retrospective Studies
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| pubmed:year |
2000
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| pubmed:articleTitle |
Association and linkage analysis of the alpha-adducin gene and blood pressure.
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| pubmed:affiliation |
Institute for Molecular Medicine, University of Texas-Houston Health Science Center, 77225, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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