Linked Life Data

1091146

Source:http://linkedlifedata.com/resource/pubmed/id/1091146

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-5-27
pubmed:abstractText
Data are presented on th sex-specific frequency and the sex ratios of anencephaly and spina bifida from 1945 through 1971. Dramatic changes in the overall rate of these malformations occurred during that period. The purpose of this study was to evaluate the concept of sex-specific thresholds for an unidentified environmental teratogen, a concept which had recently been proposed. The observed epidemiologic relationship between the frequencies and the sex ratios of these malformations is too complex to reconcile with the action of a single teratogen. On hypothetical grounds, a deficiency of human chorionic gonadotrophin (HCG) could explain the sex ratio pattern. These malformations might be caused by yet unidentified factors which produce a deficiency in HCG function. These factors could be placental teratogens, or they could be some other type of environmental agent which is capable of producing a long-term effect on maternal endocrine function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9262
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Female excess in anencephaly and spina bifida: possible gestational influences.
pubmed:publicationType
Journal Article