Source:http://linkedlifedata.com/resource/pubmed/id/10910068
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
2000-8-17
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| pubmed:abstractText |
To help clarify the molecular basis of tumor immunology in lung cancer, we have investigated antigens recognized by HLA-A24-restricted CTLs established from T cells infiltrating into lung adenocarcinoma and report a new gene encoding tumor epitopes recognized by the CTLs. This gene was located on chromosome 4q31.22 and encoded an unreported endoplasmic reticulum-resident protein with 412 deduced amino acids. This protein had a molecular mass of 46 kDa and was expressed in the majority of malignant cells and tissues tested, with the exception of T-cell leukemia cells, but was not expressed in a panel of normal cells and tissues, except in those of the testis, placenta, and fetal liver. Two peptides at positions 13-20 and 75-84 were recognized by the CTLs and had an ability to induce HLA-A24-restricted and tumor-specific CTLs in peripheral blood mononuclear cells of lung cancer patients. Thus, these peptides might be appropriate molecules for use in the specific immunotherapy of HLA-A24+ patients with lung and other cancers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3550-8
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10910068-Adenocarcinoma,
pubmed-meshheading:10910068-Amino Acid Sequence,
pubmed-meshheading:10910068-Base Sequence,
pubmed-meshheading:10910068-Chromosome Mapping,
pubmed-meshheading:10910068-Chromosomes, Human, Pair 4,
pubmed-meshheading:10910068-Female,
pubmed-meshheading:10910068-HLA-A Antigens,
pubmed-meshheading:10910068-HLA-A24 Antigen,
pubmed-meshheading:10910068-Humans,
pubmed-meshheading:10910068-Lung Neoplasms,
pubmed-meshheading:10910068-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:10910068-Male,
pubmed-meshheading:10910068-Molecular Sequence Data,
pubmed-meshheading:10910068-Molecular Weight,
pubmed-meshheading:10910068-Neoplasm Proteins,
pubmed-meshheading:10910068-Organ Specificity,
pubmed-meshheading:10910068-Recombinant Proteins,
pubmed-meshheading:10910068-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10910068-Transfection,
pubmed-meshheading:10910068-Tumor Cells, Cultured,
pubmed-meshheading:10910068-Urinary Bladder Neoplasms
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Identification of a new endoplasmic reticulum-resident protein recognized by HLA-A24-restricted tumor-infiltrating lymphocytes of lung cancer.
|
| pubmed:affiliation |
Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|