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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2000-10-10
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pubmed:abstractText |
Numerous cytokines are expressed in lesions of synovial hyperplasia of patients with rheumatoid arthritis (RA), and their pathophysiological contributions have been the subject of speculation. These genes are regulated by the transcription factor NFkappaB which in turn is activated by tumour necrosis factor-alpha (TNF-alpha) and cytokines. In this study we examined the inhibition of the production of pro-inflammatory cytokines, adhesion molecule and matrix metalloproteinase (MMP) from synovial tissue of patients with RA by the introduction of synthetic double-stranded DNA with high affinity for the NFkappaB binding site.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1462-0324
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pubmed:author |
pubmed-author:KanedaYY,
pubmed-author:KanekoMM,
pubmed-author:MorishitaRR,
pubmed-author:NakaseTT,
pubmed-author:OchiTT,
pubmed-author:ShoEE,
pubmed-author:TakahiKK,
pubmed-author:TakanoHH,
pubmed-author:TomitaNN,
pubmed-author:TomitaTT,
pubmed-author:YoshikawaHH
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
749-57
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pubmed:dateRevised |
2007-9-6
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pubmed:meshHeading |
pubmed-meshheading:10908694-Arthritis, Rheumatoid,
pubmed-meshheading:10908694-Cell Adhesion Molecules,
pubmed-meshheading:10908694-Cell Division,
pubmed-meshheading:10908694-Cytokines,
pubmed-meshheading:10908694-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10908694-Fluorescein-5-isothiocyanate,
pubmed-meshheading:10908694-Gene Therapy,
pubmed-meshheading:10908694-Humans,
pubmed-meshheading:10908694-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10908694-Interleukin-1,
pubmed-meshheading:10908694-Matrix Metalloproteinase 1,
pubmed-meshheading:10908694-NF-kappa B,
pubmed-meshheading:10908694-Oligodeoxyribonucleotides,
pubmed-meshheading:10908694-Synovial Membrane,
pubmed-meshheading:10908694-Transcription Factors,
pubmed-meshheading:10908694-Transfection,
pubmed-meshheading:10908694-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Department of Geriatric Medicine, Department of Gene Therapy Science, Osaka University Medical School, 2-2 Yamada-oka, Suita 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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