Linked Life Data

10908620

Source:http://linkedlifedata.com/resource/pubmed/id/10908620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2000-8-10
pubmed:abstractText
The thalamocortical axon (TCA) projection originates in dorsal thalamus, conveys sensory input to the neocortex, and has a critical role in cortical development. We show that the secreted axon guidance molecule netrin-1 acts in vitro as an attractant and growth promoter for dorsal thalamic axons and is required for the proper development of the TCA projection in vivo. As TCAs approach the hypothalamus, they turn laterally into the ventral telencephalon and extend toward the cortex through a population of netrin-1-expressing cells. DCC and neogenin, receptors implicated in mediating the attractant effects of netrin-1, are expressed in dorsal thalamus, whereas unc5h2 and unc5h3, netrin-1 receptors implicated in repulsion, are not. In vitro, dorsal thalamic axons show biased growth toward a source of netrin-1, which can be abolished by netrin-1-blocking antibodies. Netrin-1 also enhances overall axon outgrowth from explants of dorsal thalamus. The biased growth of dorsal thalamic axons toward the internal capsule zone of ventral telencephalic explants is attenuated, but not significantly, by netrin-1-blocking antibodies, suggesting that it releases another attractant activity for TCAs in addition to netrin-1. Analyses of netrin-1 -/- mice reveal that the TCA projection through the ventral telencephalon is disorganized, their pathway is abnormally restricted, and fewer dorsal thalamic axons reach cortex. These findings demonstrate that netrin-1 promotes the growth of TCAs through the ventral telencephalon and cooperates with other guidance cues to control their pathfinding from dorsal thalamus to cortex.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5792-801
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10908620-Animals, pubmed-meshheading:10908620-Axons, pubmed-meshheading:10908620-Caenorhabditis elegans Proteins, pubmed-meshheading:10908620-Cerebral Cortex, pubmed-meshheading:10908620-Corpus Striatum, pubmed-meshheading:10908620-Female, pubmed-meshheading:10908620-Fetus, pubmed-meshheading:10908620-Gene Expression Regulation, Developmental, pubmed-meshheading:10908620-Helminth Proteins, pubmed-meshheading:10908620-Internal Capsule, pubmed-meshheading:10908620-Mediodorsal Thalamic Nucleus, pubmed-meshheading:10908620-Membrane Proteins, pubmed-meshheading:10908620-Mice, pubmed-meshheading:10908620-Mice, Inbred ICR, pubmed-meshheading:10908620-Mice, Knockout, pubmed-meshheading:10908620-Nerve Growth Factors, pubmed-meshheading:10908620-Neural Pathways, pubmed-meshheading:10908620-Pregnancy, pubmed-meshheading:10908620-Receptors, Cell Surface, pubmed-meshheading:10908620-Receptors, Growth Factor, pubmed-meshheading:10908620-Tumor Suppressor Proteins
pubmed:year
2000
pubmed:articleTitle
Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection.
pubmed:affiliation
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.