|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011847,
umls-concept:C0011854,
umls-concept:C0014507,
umls-concept:C0015576,
umls-concept:C0017398,
umls-concept:C0023745,
umls-concept:C0086418,
umls-concept:C0205197,
umls-concept:C0231335,
umls-concept:C0332307,
umls-concept:C0441633,
umls-concept:C0936012,
umls-concept:C1257890,
umls-concept:C1521991,
umls-concept:C1539477,
umls-concept:C2603343
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2000-12-8
|
|
pubmed:abstractText |
The human Fas gene (FAS) on chromosome 10q24.1 encoding a cell surface receptor involved in apoptosis was evaluated as a candidate susceptibility gene for Type I (insulin-dependent) diabetes mellitus. Apoptosis mediated by Fas is important in maintaining peripheral self-tolerance and in down-regulating the immune response and could have a role in immune-mediated beta-cell destruction.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0012-186X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
800-8
|
|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:10907126-Adult,
pubmed-meshheading:10907126-Antigens, CD95,
pubmed-meshheading:10907126-Child,
pubmed-meshheading:10907126-Chromosome Mapping,
pubmed-meshheading:10907126-Chromosomes, Human, Pair 10,
pubmed-meshheading:10907126-DNA Primers,
pubmed-meshheading:10907126-Denmark,
pubmed-meshheading:10907126-Diabetes Mellitus, Type 1,
pubmed-meshheading:10907126-European Continental Ancestry Group,
pubmed-meshheading:10907126-Exons,
pubmed-meshheading:10907126-Female,
pubmed-meshheading:10907126-Genetic Linkage,
pubmed-meshheading:10907126-Humans,
pubmed-meshheading:10907126-Male,
pubmed-meshheading:10907126-Microsatellite Repeats,
pubmed-meshheading:10907126-Mutation,
pubmed-meshheading:10907126-Nuclear Family,
pubmed-meshheading:10907126-Polymerase Chain Reaction,
pubmed-meshheading:10907126-Polymorphism, Single-Stranded Conformational
|
|
pubmed:year |
2000
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|
pubmed:articleTitle |
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
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|
pubmed:affiliation |
Steno Diabetes Center, Gentofte, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
