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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Pt 2
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pubmed:dateCreated |
1975-6-9
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pubmed:abstractText |
Bacterial lipopolysaccharide (LPS), being a B cell mitogen, enhances antibody production. When given prior to an injection of sheep red blood cells (SRBC) it caused a premature but not significantly increased production of antibody forming cells in regionally stimulated lymph nodes. There was a corresponding depression of T cell activity, as measured by the relative levels of delayed-type hypersensitivity (DTH) in normal and LPS-treated mice. Although LPS also induced hyperplasia of the reticuloendothelial system, and a consequent reduction in the effective antigenic dose of SRBC, this was not the reason for the reduced level of T cell activity. The opposing effects of LPS on T and B cell responses was due to premature inhibition of the T cell response by an accelerated production of antibody. This caused an earlier onset of the inhibitory mechanism which regulates the T cell response and is specific for the inducing antigen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
442-6
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pubmed:dateRevised |
2009-10-27
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pubmed:meshHeading |
pubmed-meshheading:1090661-Animals,
pubmed-meshheading:1090661-Antibody Formation,
pubmed-meshheading:1090661-Antibody-Producing Cells,
pubmed-meshheading:1090661-B-Lymphocytes,
pubmed-meshheading:1090661-Chickens,
pubmed-meshheading:1090661-Cyclophosphamide,
pubmed-meshheading:1090661-Erythrocytes,
pubmed-meshheading:1090661-Female,
pubmed-meshheading:1090661-Germ-Free Life,
pubmed-meshheading:1090661-Hemagglutination Tests,
pubmed-meshheading:1090661-Hemolytic Plaque Technique,
pubmed-meshheading:1090661-Hindlimb,
pubmed-meshheading:1090661-Hypersensitivity, Delayed,
pubmed-meshheading:1090661-Immunity, Cellular,
pubmed-meshheading:1090661-Immunization, Passive,
pubmed-meshheading:1090661-Lipopolysaccharides,
pubmed-meshheading:1090661-Lymph Nodes,
pubmed-meshheading:1090661-Male,
pubmed-meshheading:1090661-Mice,
pubmed-meshheading:1090661-Organ Size,
pubmed-meshheading:1090661-Polysaccharides, Bacterial,
pubmed-meshheading:1090661-Salmonella enteritidis,
pubmed-meshheading:1090661-Sheep,
pubmed-meshheading:1090661-Spleen
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pubmed:year |
1975
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pubmed:articleTitle |
Effects of bacterial lipopolysaccharide on the induction and expression of cell-mediated immunity. I. Depression of the afferent arc.
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pubmed:publicationType |
Journal Article
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