Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 2
pubmed:dateCreated
1975-6-9
pubmed:abstractText
Spleen cells from mice immunized with a low dose of SRBC produce a greater secondary response to subsequent antigenic challenge in vivo than spleen cells from mice initially immunized with a larger dose. However, when the spleen cells are removed from the mice and given a secondary challange in tissue culture, a greater response is produced by cells from animals primed with the larger dose. Serum from the mice receiving the high dose of antigen contains low, but significant levels of specific antibody, and can inhibit further antibody production by lymphoid cells in vivo and in vitro. The characteristics of this suppression are similar to those known for passively administered specific antibody. Thus, antibody produced as a result of primary immunization may act through an inhibitory feedback mechanism in specifically limiting the magnitude of the secondary response to subsequent antigenic challenge in the normal animal
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
394-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1090658-Animals, pubmed-meshheading:1090658-Antibodies, pubmed-meshheading:1090658-Antibody-Producing Cells, pubmed-meshheading:1090658-Cells, Cultured, pubmed-meshheading:1090658-Complement System Proteins, pubmed-meshheading:1090658-Erythrocytes, pubmed-meshheading:1090658-Feedback, pubmed-meshheading:1090658-Female, pubmed-meshheading:1090658-Hemagglutination Tests, pubmed-meshheading:1090658-Hemolysin Proteins, pubmed-meshheading:1090658-Hemolytic Plaque Technique, pubmed-meshheading:1090658-Immunization, pubmed-meshheading:1090658-Immunologic Memory, pubmed-meshheading:1090658-Immunosuppression, pubmed-meshheading:1090658-Kinetics, pubmed-meshheading:1090658-Lymphocytes, pubmed-meshheading:1090658-Mice, pubmed-meshheading:1090658-Mice, Inbred DBA, pubmed-meshheading:1090658-Perissodactyla, pubmed-meshheading:1090658-Sheep, pubmed-meshheading:1090658-Spleen
pubmed:year
1975
pubmed:articleTitle
The role of antibody feedback inhibition in the regulation of the secondary antibody response after high and low dose priming.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.