Linked Life Data

10905506

Source:http://linkedlifedata.com/resource/pubmed/id/10905506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2000-8-22
pubmed:abstractText
Methyl tertiary butyl ether (MTBE), the main component of oxygenated gasoline, is added to gasoline as an octane enhancer to reduce automotive emissions. We evaluated the mutagenicity of domestic MTBE using the Ames test, unscheduled DNA synthesis (UDS) assay, and NIH/3T3 cell micronucleus test. MTBE did not show any mutagenic potential in the Ames assay (TA98, TA100 strains) with or without rat liver-derived metabolic activation system (S-9). In rat primary hepatocyte UDS assay, a dose-response relationship was observed, which meant that MTBE might damage normal DNA and induce unscheduled DNA synthesis. MTBE did not show positive results in the NIH/3T3 cell micronucleus test. It could be concluded that MTBE has some degree of mutagenicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0731-8898
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Mutagenicity of methyl tertiary butyl ether.
pubmed:affiliation
Department of Environmental Health, School of Public Health, Shanghai Medical University, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't