Linked Life Data

10904426

Source:http://linkedlifedata.com/resource/pubmed/id/10904426

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-10-13
pubmed:abstractText
Uteroplacental vascular adaptation during pregnancy depends on retrograde endovascular migration of trophoblast in the uterine spiral arteries and their subsequent incorporation into the vessel wall. In the human, this migration process occurs in a step-wise fashion, starting with plugging of the distal ends of the arteries, followed by migration into the decidual and, after several weeks' delay, into the myometrial segments. The hypothesis is put forward that haemodynamical forces play an important regulatory role in this process. A mechanical signal transduction system should then be present within the trophoblastic cells to trigger their rheotactic behaviour. Since the condition of preeclampsia is characterized by restricted colonization of spiral arteries by trophoblast, the implications of this proposed regulatory system on the pathogenesis of the disease are considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-9877
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Harcourt Publishers Ltd.
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Uterine haemodynamics as a possible driving force for endovascular trophoblast migration in the placental bed.
pubmed:affiliation
Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, Belgium.
pubmed:publicationType
Journal Article