Linked Life Data

1090393

Source:http://linkedlifedata.com/resource/pubmed/id/1090393

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1975-5-27
pubmed:abstractText
The effect of intravenous infusion of 10 per cent glycerol on regional cerebral blood flow (using hydrogen bolus and Xenon-133 (133Xe) clearance methods) and metabolism was investigated in 57 patients with recent cerebral infarction. Hemispheric blood flow (HBF) increased, together with increase in regional cerebral blood flow (rCBF) and cerebral blood volume (rCBV), in foci of brain ischemia. Hemispheric oxygen consumption (HMIO2) decreased together with hemispheric respiratory quotient. Systemic blood levels of glucose, lactate, pyruvate, and triglycerides also increased after glycerol while free fatty acids (FFA) and inorganic phosphate (Pi) decreased. Hemispheric glucose consumption was unaltered after glycerol so that hemispheric glucose to oxygen ratio tended to rise. Pyruvate and lactate production by brain was unchanged. Glycerol moved across the blood brain barrier into brain and cerebrospinal fluid (CSF). Release of FFA and Pi from infarcted brain was reversed by glycerol. Total phosphate balance was maintained actoss brain both before and after glycerol infusion. Triglycerides increased in CSF after glycerol, originating either from cerebral blood or as a result of lipogenesis in cerebral tissue. The EEG Recording and neurological status of the patients improved despite decreased brain oxygen consumption. Results of this study suggest that after intravenous infusion of 10 per cent glycerol in patients with recent cerebral infarction, glycerol rapidly enters the CSF and brain compartments and favorably affects the stroke process in two ways: first, by redistribution of cerebral blood flow with increase in rCBF and rCBV in ischemic brain secondary to reduction in focal cerebral edema; and second glycerol may become an alternative source of energy either by being directly metabolized by the brain, or indirectly, by enhancing lipogenesis, or by both processes. Involvement of glycerol in lipogenesis with esterification to accumulated FFA might lead to improved coupling of oxidative phosphorylation, a hypothesis that fits the finding of improved neuronal function despite further decrease in cerebral hemispheric oxygen consumption.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0009-7322
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
701-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1090393-Aged, pubmed-meshheading:1090393-Brain, pubmed-meshheading:1090393-Cerebrovascular Circulation, pubmed-meshheading:1090393-Cerebrovascular Disorders, pubmed-meshheading:1090393-Energy Metabolism, pubmed-meshheading:1090393-Fatty Acids, Nonesterified, pubmed-meshheading:1090393-Female, pubmed-meshheading:1090393-Glucose, pubmed-meshheading:1090393-Glycerol, pubmed-meshheading:1090393-Humans, pubmed-meshheading:1090393-Hydrogen, pubmed-meshheading:1090393-Indicator Dilution Techniques, pubmed-meshheading:1090393-Infusions, Parenteral, pubmed-meshheading:1090393-Lactates, pubmed-meshheading:1090393-Male, pubmed-meshheading:1090393-Middle Aged, pubmed-meshheading:1090393-Oxidative Phosphorylation, pubmed-meshheading:1090393-Oxygen Consumption, pubmed-meshheading:1090393-Phosphates, pubmed-meshheading:1090393-Pyruvates, pubmed-meshheading:1090393-Radioisotope Dilution Technique, pubmed-meshheading:1090393-Triglycerides, pubmed-meshheading:1090393-Xenon
pubmed:year
1975
pubmed:articleTitle
Circulatory and metabolic effects of glycerol infusion in patients with recent cerebral infarction.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.