| pubmed-article:10903752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:10903752 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10903752 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10903752 | pubmed:dateCreated | 2000-8-22 | lld:pubmed |
| pubmed-article:10903752 | pubmed:abstractText | The T cell coreceptor, CD8, enhances T cell-APC interactions. Because soluble CD8alpha homodimers can antagonize CD8 T cell activation in vitro, we asked whether secretion of soluble CD8 would effect cytotoxic T cell responses in vivo. Production of soluble CD8 by a replication-defective adenovirus vector allowed persistent virus expression for up to 5 mo in C57BL/6 mice and protected a second foreign transgene from rapid deletion. Soluble CD8 selectively inhibited CD8 T cell proliferation and IFN-gamma production and could also attenuate peptide-specific CD8 T cell responses in vivo. These finding suggest that gene vector delivery of soluble CD8 may have therapeutic applications. | lld:pubmed |
| pubmed-article:10903752 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10903752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10903752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10903752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10903752 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10903752 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10903752 | pubmed:author | pubmed-author:ElkonK BKB | lld:pubmed |
| pubmed-article:10903752 | pubmed:author | pubmed-author:PengYY | lld:pubmed |
| pubmed-article:10903752 | pubmed:author | pubmed-author:Falck-Pederse... | lld:pubmed |
| pubmed-article:10903752 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10903752 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10903752 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:10903752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10903752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10903752 | pubmed:pagination | 1470-8 | lld:pubmed |
| pubmed-article:10903752 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10903752 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10903752 | pubmed:articleTitle | Soluble CD8 attenuates cytotoxic T cell responses against replication-defective adenovirus affording transprotection of transgenes in vivo. | lld:pubmed |
| pubmed-article:10903752 | pubmed:affiliation | Departments ofMedicine and Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:10903752 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10903752 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10903752 | lld:pubmed |
