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rdf:type |
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lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0282641,
umls-concept:C0599946,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515655,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C1749467,
umls-concept:C2698600,
umls-concept:C2911692
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2000-8-22
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|
pubmed:abstractText |
The T cell coreceptor, CD8, enhances T cell-APC interactions. Because soluble CD8alpha homodimers can antagonize CD8 T cell activation in vitro, we asked whether secretion of soluble CD8 would effect cytotoxic T cell responses in vivo. Production of soluble CD8 by a replication-defective adenovirus vector allowed persistent virus expression for up to 5 mo in C57BL/6 mice and protected a second foreign transgene from rapid deletion. Soluble CD8 selectively inhibited CD8 T cell proliferation and IFN-gamma production and could also attenuate peptide-specific CD8 T cell responses in vivo. These finding suggest that gene vector delivery of soluble CD8 may have therapeutic applications.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
165
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1470-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10903752-Adenoviridae,
pubmed-meshheading:10903752-Animals,
pubmed-meshheading:10903752-Antigens, CD8,
pubmed-meshheading:10903752-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10903752-Cytotoxicity, Immunologic,
pubmed-meshheading:10903752-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:10903752-Defective Viruses,
pubmed-meshheading:10903752-Epitopes, T-Lymphocyte,
pubmed-meshheading:10903752-Gene Expression Regulation,
pubmed-meshheading:10903752-Genetic Vectors,
pubmed-meshheading:10903752-Immunosuppressive Agents,
pubmed-meshheading:10903752-Injections, Intravenous,
pubmed-meshheading:10903752-Liver,
pubmed-meshheading:10903752-Lymphocyte Activation,
pubmed-meshheading:10903752-Mice,
pubmed-meshheading:10903752-Mice, Inbred BALB C,
pubmed-meshheading:10903752-Mice, Inbred C3H,
pubmed-meshheading:10903752-Mice, Inbred C57BL,
pubmed-meshheading:10903752-Mice, Transgenic,
pubmed-meshheading:10903752-Ovalbumin,
pubmed-meshheading:10903752-Recombinant Fusion Proteins,
pubmed-meshheading:10903752-Solubility,
pubmed-meshheading:10903752-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10903752-Transgenes,
pubmed-meshheading:10903752-Virus Replication
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
Soluble CD8 attenuates cytotoxic T cell responses against replication-defective adenovirus affording transprotection of transgenes in vivo.
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|
pubmed:affiliation |
Departments ofMedicine and Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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