Linked Life Data

10903573

Source:http://linkedlifedata.com/resource/pubmed/id/10903573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2000-8-15
pubmed:abstractText
We report that variations in maternal care in the rat promote hippocampal synaptogenesis and spatial learning and memory through systems known to mediate experience-dependent neural development. Thus, the offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of NMDA receptor subunit and brain-derived neurotrophic factor (BDNF) mRNA, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. A cross-fostering study provided evidence for a direct relationship between maternal behavior and hippocampal development, although not all neonates were equally sensitive to variations in maternal care.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1097-6256
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
799-806
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Maternal care, hippocampal synaptogenesis and cognitive development in rats.
pubmed:affiliation
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Departments of Psychiatry and Neurology & Neurosurgery, McGill University, 6875 Boul. LaSalle, Montréal H4H 1R3, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't