Linked Life Data

10903536

Source:http://linkedlifedata.com/resource/pubmed/id/10903536

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-9-14
pubmed:abstractText
We report on the transient, patterned expression of p75 in the ventrobasal (VB) thalamus, the major thalamic relay for somatosensation. We immunostained the brains of developing rats ranging in age from embryonic day (E) 14.5 to postnatal day (PD) 15 with an antibody against p75. To compare p75 expression with the developing synaptic organization within VB, we also immunolocalized the synaptic-vesicle-associated protein, synaptophysin (SYN), on alternate sections. p75-immunoreactivity (IR) was dense and uniform in the ventroposterior medial nucleus (VPM) in the late embryonic and early postnatal periods (E 16.5 to PD 3). In contrast, from PD 4-10, p75-IR in the VPM was patterned, reminiscent of cytochrome-oxidase-stained barreloids, a characteristic feature of the VB in rodents. By PD 14, p75-IR in the VPM was no longer detectable. The ventroposterior lateral nucleus (VPL), in contrast, exhibited no p75-IR. No p75-IR was detected in the ventroposterior lateral nucleus (VPL) at any developmental stage in which VPM could be distinguished from VPL. Light, but clearly patterned SYN-IR, first detectable on PD 2-3, increased in intensity in both VPL and VPM through PD 15. Sectioning the infraorbital nerve on PD 0 resulted in blurred patterns of p75- and SYN-IR within VPM in PD 7-9 rat pups. Removing large portions of the somatosensory cortex on PD 0 resulted in subsequent greatly reduced p75- and SYN-IR within VB. To specify the source of the p75-IR terminals, we stereotaxically injected into the VPM of PD 4-5 rats a monoclonal antibody to p75. One to 2 days later, IR of retrogradely transported p75 antibodies could be traced within axons and cell bodies of neurons associated with the trigeminothalamic pathway through the caudal diencephalon and mesencephalon; labelling was confined to the contralateral trigeminal principal sensory nucleus. The observed, transiently patterned p75-IR in VPM the early postpartum period suggests a role for p75 in synaptogenesis and pattern formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-276X
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
259
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
446-60
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:10903536-Age Factors, pubmed-meshheading:10903536-Animals, pubmed-meshheading:10903536-Animals, Newborn, pubmed-meshheading:10903536-Carrier Proteins, pubmed-meshheading:10903536-Female, pubmed-meshheading:10903536-Fetus, pubmed-meshheading:10903536-Nerve Tissue Proteins, pubmed-meshheading:10903536-Neurons, pubmed-meshheading:10903536-Pregnancy, pubmed-meshheading:10903536-Rats, pubmed-meshheading:10903536-Rats, Long-Evans, pubmed-meshheading:10903536-Receptors, Growth Factor, pubmed-meshheading:10903536-Receptors, Nerve Growth Factor, pubmed-meshheading:10903536-Somatosensory Cortex, pubmed-meshheading:10903536-Synapses, pubmed-meshheading:10903536-Trigeminal Nerve, pubmed-meshheading:10903536-Trigeminal Nuclei, pubmed-meshheading:10903536-Ventral Thalamic Nuclei, pubmed-meshheading:10903536-Vibrissae
pubmed:year
2000
pubmed:articleTitle
Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: development, response to injury, transient vibrissa-related patterning, and retrograde transport.
pubmed:affiliation
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA. crockett@umdnj.edu
pubmed:publicationType
Journal Article