Linked Life Data

10902911

Source:http://linkedlifedata.com/resource/pubmed/id/10902911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2000-11-24
pubmed:databankReference
pubmed:abstractText
The Na+/Ca2+ exchanger gene NCX1 is ubiquitously expressed in mammalian tissues, and encodes several isoforms through alternative RNA splicing. In this report, we describe the gene structure that gives rise to the multiple isoforms, and the tissue-specific expression of these isoforms in mice. The mouse NCX1 gene contains a cluster of six exons (A, B, C, D, E, and F) which encode a variable region in the large intracellular loop of the protein, as previously reported in rabbits and humans. Using reverse transcription-polymerase chain reaction (RT-PCR), expression of the isoforms was examined in several tissues. We also identified a novel splice variant, which originate from exons A, C, D, and F. These findings provide new insights into the significance of the large repertoire of NCX1 isoforms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1042-5179
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-81
pubmed:dateRevised
2006-10-19
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice.
pubmed:affiliation
Advanced Medical Research Department, Tanabe Seiyaku Co. Ltd, Osaka, Japan.
pubmed:publicationType
Journal Article