Linked Life Data

10902868

Source:http://linkedlifedata.com/resource/pubmed/id/10902868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-10-16
pubmed:abstractText
Human chorionic gonadotrophin (hCG) has been used as a serum biochemical marker of Down's syndrome (DS) pregnancies, and recent studies have reported an increase in a hyperglycosylated form of the protein associated with DS. In the present study, the activity of the combined soluble serum sialyltransferase (ST) enzymes was examined as a potential marker for the hyperglycosylated form of hCG. There were no changes in total ST activity during the course of the pregnancy in normal mothers and there was no difference in enzyme activity in the DS pregnancies when compared with controls. These results suggest that, although there may be an alteration in the activities of one or more of the glycosyltransferase enzymes in the placenta resulting in an alteration in hCG glycosylation, this is not reflected in the serum soluble enzyme activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0004-5632
pubmed:author
pubmed:issnType
Print
pubmed:volume
37 ( Pt 4)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Serum expression of sialyltransferase in normal and Down's syndrome-affected pregnancy.
pubmed:affiliation
Department of Biological Chemistry, University of Athens, Medical School, Greece. biolchem@ath.forthnet.gr
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't