Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2000-8-24
pubmed:abstractText
Previous studies showed that decorin-binding protein A (DbpA) of Borrelia burgdorferi was a protective immunogen in the murine model of Lyme borreliosis when mice were challenged (needle inoculated) intradermally with in vitro-cultivated spirochetes. In the present study, DbpA-immunized C3H/HeJ mice were not protected from infection when infested with Ixodes scapularis nymphs harboring virulent B. burgdorferi 297. This lack of protection correlated with the failure to detect DbpA on B. burgdorferi in ticks, suggesting that DbpA is not available as a target for bactericidal antibodies in serum when B. burgdorferi-infected ticks take their blood meal from an immunized host. The failure of DbpA immunization to protect tick-challenged mice contradicts the results of earlier needle inoculation vaccination experiments and suggests that DbpA may not be suitable as a Lyme disease vaccine.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-10094620, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-10338494, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-10473582, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-10531261, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-1608951, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-3819479, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-7485694, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-7545508, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-7591099, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-7642279, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-7708747, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8121286, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8478108, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8551231, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8755587, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8805079, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8843211, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-8985202, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9573101, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9593780, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9596733, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9596756, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9673298, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9673299, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9673306, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899883-9784547
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4759-64
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks.
pubmed:affiliation
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.