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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2000-10-19
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pubmed:abstractText |
Based on amino acid sequence comparisons, Pax1 and Pax9 genes are considered to form a subgroup of vertebrate Pax genes. We show here that the gene structures of mouse Pax1, human PAX9 genes are similar to that of a single Pax1/9 related gene in Branchiostoma lanceolatum, AmphiPax1. This supports the hypothesis that Pax1 and Pax9 genes were derived from a single ancestral gene. A refined protein alignment of AmphiPax1, mouse Pax1 and human PAX9 proteins based on the determined exon boundaries indicates that sequence divergence at the C-termini may be related to the unique functions of the Pax1 and Pax9 genes in vertebrates. AmphiPax1 is expressed in adult amphioxus in the pharyngeal endoderm.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
1492
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10899593-Amino Acid Sequence,
pubmed-meshheading:10899593-Animals,
pubmed-meshheading:10899593-Chordata, Nonvertebrate,
pubmed-meshheading:10899593-Conserved Sequence,
pubmed-meshheading:10899593-DNA-Binding Proteins,
pubmed-meshheading:10899593-Evolution, Molecular,
pubmed-meshheading:10899593-Genome,
pubmed-meshheading:10899593-Humans,
pubmed-meshheading:10899593-Mice,
pubmed-meshheading:10899593-Molecular Sequence Data,
pubmed-meshheading:10899593-PAX9 Transcription Factor,
pubmed-meshheading:10899593-Paired Box Transcription Factors,
pubmed-meshheading:10899593-Sequence Homology, Amino Acid,
pubmed-meshheading:10899593-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Evolutionary conservation of gene structures of the Pax1/9 gene family.
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pubmed:affiliation |
Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, Stuebeweg 51, D-79108, Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study
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