Linked Life Data

10899403

Source:http://linkedlifedata.com/resource/pubmed/id/10899403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-10-6
pubmed:abstractText
B21 is a radula mechanoafferent neuron in the mollusc Aplysia which likely plays a crucial role in integrating environmental cues into the feeding motor program. To facilitate understanding B21's interactions with its postsynaptic followers, we sought to identify its neurotransmitter. We find that B21 makes a chemical synapse onto the follower neuron B8. Although B21-induced excitatory postsynaptic potentials (EPSPs) in B8 paradoxically diminish in amplitude with B8 hyperpolarization, we show that an inwardly rectifying current is responsible. We conclude that these B21-induced EPSPs are likely glutamatergic as they are blocked by the glutamate antagonist DNQX. Furthermore, B8 exhibits a depolarizing response to exogenous glutamate, which is antagonized by DNQX. Finally, exogenous glutamate occludes B21-evoked EPSPs in B8.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
289
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Glutamate is the fast excitatory neurotransmitter of small cardioactive peptide-containing Aplysia radula mechanoafferent neuron B21.
pubmed:affiliation
Department of Physiology and Biophysics, Box 1218, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA. ak1@doc.mssm.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't