Source:http://linkedlifedata.com/resource/pubmed/id/10896894
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2000-9-27
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| pubmed:abstractText |
These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after spinal cord injury (SCI). In urethan-anesthetized Wistar rats after SCI for 6 wk, intravesical saline distension significantly (P </= 0.005) increased the number of Fos-immunoreactive (IR) cells in the rostrolumbar (L1, 38 cells/section; L2, 29 cells/section) and caudal lumbosacral (L6, 140 cells/section; S1, 110 cells/section) spinal cord compared with control animals, but Fos expression in the L5 segment was not altered. The distribution of Fos-IR cells was also altered in the lumbosacral spinal cord. Significantly greater numbers of Fos-IR cells were distributed in the dorsal commissure and medial and lateral dorsal horn after intravesical distension in SCI animals. Large percentages of parasympathetic (75%) and sympathetic (85%) preganglionic neurons also expressed Fos-IR after intravesical distension in SCI animals. These results demonstrate that bladder distension produces increased numbers and an altered distribution pattern of Fos-IR cells after SCI. This pattern resembles that after noxious irritation of the bladder in control animals. Pretreatment with capsaicin significantly reduced the number of Fos-IR cells induced by bladder distension after SCI. These data suggest that SCI can reveal an altered Fos expression pattern in response to a nonnoxious bladder stimulus that is partially mediated by capsaicin-sensitive bladder afferents.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Choline O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0363-6119
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
279
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
R295-305
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10896894-Acetic Acid,
pubmed-meshheading:10896894-Administration, Intravesical,
pubmed-meshheading:10896894-Animals,
pubmed-meshheading:10896894-Autonomic Fibers, Preganglionic,
pubmed-meshheading:10896894-Capsaicin,
pubmed-meshheading:10896894-Cell Count,
pubmed-meshheading:10896894-Choline O-Acetyltransferase,
pubmed-meshheading:10896894-Lumbosacral Region,
pubmed-meshheading:10896894-Nerve Fibers,
pubmed-meshheading:10896894-Neurons,
pubmed-meshheading:10896894-Organ Size,
pubmed-meshheading:10896894-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:10896894-Rats,
pubmed-meshheading:10896894-Rats, Wistar,
pubmed-meshheading:10896894-Sodium Chloride,
pubmed-meshheading:10896894-Spinal Cord,
pubmed-meshheading:10896894-Spinal Cord Injuries,
pubmed-meshheading:10896894-Urinary Bladder,
pubmed-meshheading:10896894-Urinary Tract
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| pubmed:year |
2000
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| pubmed:articleTitle |
Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injury.
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| pubmed:affiliation |
University of Vermont College of Medicine, Departments of Neurology and Anatomy and Neurobiology, Burlington, Vermont 05405, USA. mvizzard@zoo.uvm.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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